Within the 38 genes, 17 genes (ZMAT1, APBB3, MNS1, AP3M2, BTN3A1, KCNN3, TTC3, SMOC2, LUM, ASPN, FRZB, SFRP4, MATN2, ISLR, PDE5A, ECM2, and FREM1) were highly expressed in HF and 20 genes (FAM58A, CSDC2, C15orf59, S1PR3, VSIG4, CD163, SEMA4B, SLCO4A1, SERPINA3, GGT5, FURIN, ZDHHC16, LAD1, USP31, TUBA3D, TUBA3E, ST6GALNAC3, LCN6, HMOX2, and FCN3) were lowly expressed in HF. The gene discussed is SFRP4; the disease is hydrops fetalis.