ACSS2 and hepatocellular carcinoma: Comerford et al. (2014) also showed that ACSS2 knockout mice had reduced tumor burden in two models of hepatocellular carcinoma, indicating that acetate conversion to acetyl-CoA by ACSS2 was an important factor in promoting tumor growth in this cancer type. Paradoxically, Hur et al. (2015) showed that the loss of ACSS2 expression in gastric cancer correlated with poor survival and outcomes. Similarly, loss of ACSS2 expression was associated with increased aggressiveness and progression of colorectal cancer (Bae et al., 2016).