Furthermore, in a randomized, open, parallel-controlled study involving 176 patients with T2D and asymptomatic hyperuricemia, allopurinol effectively lowered sUA, improved insulin resistance, reduced serum high-sensitivity C-reactive protein (hs-CRP) level, decreased carotid intima-media thickness, and ameliorated the exacerbation of atherosclerosis (Liu et al., 2015). The gene discussed is CRP; the disease is hyperuricemia.