JAK2 and Hepatic fibrosis: (2017) have found that phosphorylated JAK2/STAT3 signal pathway can induce the expression of inflammatory cytokines in the process of liver fibrosis, and continuously secrete extracellular matrix ECM through positive feedback regulation of continuous activation of HSC; P. perfoliatum flavonoids can down-regulate the expression of α-SMA, TGF- β1, IL-1β, and IL-6, inhibit the activation of JAK2/STAT3 signal pathway, and improve liver pathological changes.