ACE2 and infection: The most studied pathway for infection involves binding to the receptor angiotensin-converting enzyme 2 (ACE2), which together with other components of angiotensin system is expressed in the CNS, mostly by endothelial cells (Zeisel et al., 2015) but also by both neurons and neuroglial cells (Xia and Lazartigues, 2010; Gowrisankar and Clark, 2016; Tekin et al., 2018; Nemoto et al., 2020).