For example, AD-associated genes APP, Apolipoprotein E, and BACE1 are hypomethylated in AD brains with concomitant BACE1 activation increasing Aβ levels via the amyloidogenic processing pathway (West et al., 1995; Tulloch et al., 2018; Li et al., 2019). The gene discussed is APOE; the disease is Alzheimer disease.