The Kdm6 family includes Kdm6a (histone lysine demethylase 6a, also known as Utx) and Kdm6b (also known as Jmjd3), and has been shown to play important roles in a multitude of cellular processes, including differentiation [5, 6], senescence [7], somatic and germ cell reprogramming [8], cancer [9] and the inflammatory response [10]. The gene discussed is KDM6B; the disease is cancer.