Analysis of human cancer genome databases (International Society for Gastrointestinal Hereditary Tumors (InSIGHT), Clinically relevant variants (ClinVAr), and the Catalog of Somatic Mutations in Cancer (COSMIC)) revealed, for all here-identified yeast MLH2 mutations, homolog substitutions in human MLH genes (hMLH1, hPMS2, and hPMS1) (Supplementary Table 5). Here, PMS1 is linked to cancer.