Natriuretic Peptides (NPs), including B-type Natriuretic Peptide (BNP) and N-terminal pro BNP (NT-proBNP), are the most reliable biomarkers for identifying people with heart failure (HF), both in heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), previously known as diastolic and systolic HF, respectively5. The gene discussed is NPPB; the disease is hydrops fetalis.