ITM2B and early-onset autosomal dominant Alzheimer disease: To further confirm that Bri2 BRICHOS-mCherry binds to amyloid fibrils, we tested Aβ42E22G (the so-called Arctic mutation related to familial Alzheimer's disease32) and a part of the central core region R3 (V306-K317) of Tau (referred to as PHF6) implicated in Tauopathies (e.g. Alzheimer’s disease and Parkinson’s disease), which resulted in similar results (Supplementary Figure 2).