Newborn male ddY, Institute for Animal Reproduction (DIAR)-nSTZ mice we adopted have had an HCC onset at 12–19 W, and the process of HCC development from dysplastic nodule to well-differentiated HCC involved the expression of tumor markers (Glypican-3 and heat shock protein 70)9. The gene discussed is GPC3; the disease is hepatocellular carcinoma.