Other observed thrombophilic conditions included inherited thrombophilic conditions (factor V Leiden mutation, prothrombin mutation G20210A, JAK2 kinase mutation, MTHFR mutation and protein S deficiency), hematological disorders (myeloproliferation, anemia and lymphoma), Crohn’s disease, prostate cancer, craniocerebral trauma and smoking. This evidence concerns the gene MTHFR and hereditary thrombophilia due to congenital protein S deficiency.