Rare non-desmosomal variants in TMEM43, TTN, TGFB3, RYR2, PLN, LMNA, DES, and CTNNA3 comprise less than 1% of all ARVC cases and have been reported in only a few families or clustering in specific areas, such as TMEM43 in Newfoundland, Canada, and PLN in The Netherlands5,6. Here, TMEM43 is linked to arrhythmogenic right ventricular cardiomyopathy.