Since ARVC has also been associated with mutations in 13 other genes, besides JUP, including PKP2, DSC2, DSG2, RYR2, SCN5A, TMEM43, DSP, CTNNA3, TGFB3, DES, LMNA, PLN and TTN, the corresponding sequences were individually checked from the RNA-Seq data, and no pathogenic variants were found in these genes. The gene discussed is DSC2; the disease is Arrhythmogenic right ventricular dysplasia.