TNFRSF11A and neoplasm: In RANK+/+ tumors early treatment (72 h after tumor implantation) with anti-RL did not affect tumor growth; however, anti-CTLA4 combined with anti-RL reduced tumor growth to a greater extent than did single anti-CTLA4 treatment (28.5% of implanted tumors did not even grow) (Fig. 4b, c).