Fewer cytokines/chemokines were more abundant in RANK−/− than in RANK+/+ tumor supernatants and included the following: (i) eotaxin 1, which is involved in eosinophil recruitment; (ii) CD40, which enhances T-cell responses; and (iii) B lymphocyte chemoattractant (BLC), which controls B-cell trafficking28 (Fig. 3a). The gene discussed is CD40; the disease is neoplasm.