CTLA4 and metastatic melanoma: The benefit of the combined effect of anti-RL and immune-checkpoint inhibitors will be investigated in the CHARLI trial (NCT03161756), a phase I/II study of the effect of denosumab in combination with nivolumab (an anti-PD-1), with or without ipilimumab (anti-CTLA4), in metastatic melanoma patients, and in the POPCORN trial (ACTRN12618001121257), which will evaluate immune changes in NSCLC patients treated with nivolumab alone or in combination with denosumab.