Nevertheless, the expression of several mitochondrial proteins (TOM40, TIM23, and Sirt3), as well as mRNA (cox1, mt-nd4) was markedly reduced in older but not in younger DCM patients (Figures 2, 3, Supplementary Figure 2 and Supplementary Figure 3, respectively). This evidence concerns the gene TIMM23 and familial dilated cardiomyopathy.