Also, in human ESCC as reported, microRNA-34a decreased CD44 expression through interacting with a putative binding site of CD44 3′ untranslated region, and CD44 knockdown could reverse the facilitation effects of microRNA-34a knockdown on tumor growth and metastasis of human ESCC cells (ECA109 and TE-13) [33]. The gene discussed is CD44; the disease is esophageal squamous cell carcinoma.