Consistent with the lack of GLI1 induction by upregulation of GLI2, we observed no effects of EZH2 and gamma secretase inhibitors and miRNA-34a rescue on GLI1 expression in HOTAIR-expressing fibroblasts (Fig. S2A) or in SSc fibroblasts (Fig. S2B). The gene discussed is EZH2; the disease is systemic sclerosis.