The function of the ERRα and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) transcriptional axis in the metabolic reprogramming of cancer cells toward mitochondrial metabolism in breast, melanoma, ovarian, prostate, and colorectal tumors is well-known [12, 28–32]. The gene discussed is PPARGC1A; the disease is melanoma.