Notably, we have performed endogenous IP against ERRα in 293T cells (p53 wild-type) and a colon cancer cell line DLD-1 (p53 mutant), and we showed that PGC-1α does not act as a surrogate protein ligand of the ERRα/p53 complex (additional file Fig. S1D). This evidence concerns the gene ESRRA and colonic neoplasm.