Intriguingly, comparing the absence of ERRα only (ii) or the absence of p53 only (iii) to the presence of the ERRα and p53 complex (i) indicated that the absence of the function of a single protein (ERRα or p53) affected central metabolism, such as glycolysis and carbon metabolism, by increasing the activation of KEGG pathways, and dramatically decreased the activation of KEGG pathways associated with mitochondrial metabolism, such as Parkinson’s disease and OxPhos (FDR ≤ 0.05; additional file Fig. S4B, C, Table S1). Here, TP53 is linked to Parkinson disease.