CSF2 and neoplasm: In addition, rather than stringent TH1 or TH2 subtypes, the predominant anti-tumor response is dependent on a highly mixed TH1/TH2 function in the same cell, suggesting the activation of BsAb-directed T cells or CAR T cells is a canonical process that leads to a mixed response combining both TH1 and TH2 cytokines together with GM-CSF [49].