MDM2 and chronic kidney disease: As can be seen, the assignment of 13 of the top 15 predicted genes is supported by recent studies, including all the top five predicted for “cell-cell communication” and “cell surface interactions at the vascular wall.” For example, Serpine1, predicted as the 2nd ranked for integrin, was shown to regulate cell migration using receptor-mediated adhesion [33], and Mdm2 (predicted for cell communication) was shown to relocate to the cell membrane during acute kidney injury-chronic kidney disease [36].