NLRP3 and cryopyrin-associated periodic syndrome: Reduced NLRP3-NEK7 complex formation abolishes the LPS-induced assembly of the inflammasome, preventing the production of, for example, IL-1β, and in PBMCs from subjects exhibiting the IL-1β based disease cryopyrin-associated periodic syndrome (CAPS) itaconate and 4-octyl itaconate reduce IL-1β production.