GPC1 and colorectal cancer: Li et al. demonstrated that GPC1 is enriched in exosomes produced by colorectal cancer cells HT-29 and HCT-116, and increased expression level of miR-96-5p and miR-149 can restrain both GPC1 expression and cell proliferation of the tumor, suggesting that GPC1 can be used as a marker for diagnosis and therapy of colorectal cancer [36].