F2R and ischemia: Their activation occurs through proteolytic cleavage of the N-terminal domain by proteinases, resulting in the generation of a new N-terminal that binds to the receptor itself, and its autoactivation.39 So far, four members of the PAR family have been discovered, PAR1, PAR2, PAR3, and PAR4.40 Since PAR1, previously known as the thrombin receptor, plays a significant role in coagulation and inflammation, a high interest arose on its involvement in the hypercoagulable state and ischemia associated with SARS-CoV-2.