CNR1 and neurodegenerative disease: As far as the CB1R is concerned, although the receptor seems to also be involved in maintaining the glutamate NMDAR activity within safe limits, thereby protecting neural cells from excitotoxicity; although the direct activation of the receptor seems responsible for effects of other long-time known drugs such as the analgesic paracetamol; and although targeting the CB1R is considered a proper direction against neurodegenerative diseases and neuroinflammation [52]—the possible psychoactive effects of the receptor activation via orthosteric ligands cannot be ignored.