CALR and systemic lupus erythematosus: The pathophysiology of SLE involves a deficit in the clearance of apoptotic cells (debris) and the loss of tolerance towards nuclear antigens such as double stranded DNA (dsDNA), Smith antigen (Sm), ribonuclear proteins (RNP), Sjögren’s-syndrome-related antigen A and B (SSA/Ro and SSB/La) among others [2].