SLC7A1 and Hypertension: Given the prominent role of CAT1 in cellular uptake and exchange of L-arginine and its emerging links to vascular function and hypertension (Table 4), CAT1 deserves further investigation not only as a target for adverse drug effects affecting CAT1-mediated uptake of L-arginine, but also as potential target to modulate the uptake and distribution of L-arginine and its derivatives in cardiovascular disease.