In mice, disruption of PTEN activity by increasing Akt phosphorylation at Ser437 produces severe changes in the population of OPCs and in the genes and proteins involved in myelination (MBP, PLP, and myelin-associated glycoprotein-MAG), which induces social deficits that mimic some symptoms of ASD [156], such as increased anxiety and reduced social interest [153]. The gene discussed is MAG; the disease is Anxiety.