ARF6 and head and neck squamous cell carcinoma: Indeed, ARF6 plays a role in EGFR-driven tumorigenesis, where it acts downstream of EGFR and GEP100 to induce invasion and malignancy in breast cancer [99], EMT in head and neck squamous cell carcinoma (HNSCC) [100] and invasion and prognosis in NSCLC [101].