Based on the OS-related ARG signature risk score, the gene sets of the high-risk group were mainly enriched in cancer- and metastasis-related pathways, including KEGG (pathways in cancer, regulation of actin cytoskeleton and focal adhesion) and REACTOME (pathways of degradation of the extracellular matrix and signaling by VEGF) (Figure 8A–E). The gene discussed is VEGFA; the disease is cancer.