As higher expression of SNHG14 is associated with increased NSCLC cell proliferation, invasion, and migration, and silencing of SNHG14 causes sensitivity to cisplatin [24], our data suggests that the monofunctional complex could signal through the miR-34a-HMGB1 axis to promote resistance mechanisms if miR-34a expression occurs. This evidence concerns the gene SNHG14 and non-small cell lung carcinoma.