High sTILs (defined as TILs > 60%) were observed in 36% in BRCA1- and 15% in BRCA2-mutated tumors (p < 0.0001). Significant association with survival (OS and DFS) was observed in BRCA1 subgroup. sTILs are an important prognostic factor in BRCA BC and increasing sTILs is associated with a better prognosis. This evidence concerns the gene BRCA1 and breast cancer.