In these cancers, p53 mutants bound to and upregulated the genes encoding KMT2A, KMT2D, and acetyltransferase MOZ (KAT6A), resulting in the global enhancement of H3K4 methylation and histone acetylation, as well as upregulation of the KMT2A target genes, including the HOXA gene cluster. The gene discussed is TP53; the disease is cancer.