A recent study demonstrated in a young man with NF1-GBM (neurofibromatosis 1-glioblastoma) that somatic mutations in KMT2B leading to protein truncation were early driver events of malignant gliomagenesis, whereas other pan-cancer genes were mutated later, as revealed by whole-genome sequencing of the patient’s brain samples analyzed at different times of the disease development [163]. Here, KMT2B is linked to glioblastoma.