While several serum biomarkers are investigated in melanoma patients [19], diagnostic markers currently applied in clinics are restricted to S-100, HMB-45, Melan-A, and SM5-1 [20,21], and the prognostic markers to monitor melanoma progression are S100B, MART1, PMEL, and S100A13 [22]. The gene discussed is S100B; the disease is melanoma.