ADCY1 and cancer: Figure 2a presents the separation in the two adenylate cyclase genes (ADCY4, ADCY6) subspace of the expression levels. In this subspace, the center of PTA was at 0.97 expression units from the center of NOR, the center of PTB at 0.77 units, and that of MET at 1.47 units. With respect to NOR, each of the two genes was upregulated in all three cancer regions: ADCY4 (by 1.66×, 2.01×, 1.57×), ADC6 (by: 2.29×, 1.40×, 3.14×). However, ADCY4 had significantly higher expression in PTB than in PTA and CWM, while ADCY6 had significantly lower expression in PTB.