Like other groups before, we too have found (but with stronger quantifiers and an absolute fold-change cutoff that takes into account the combined contributions of the biological variability and technical noise) that cancer regulates numerous genes from major functional pathways (apoptosis, basal transcription factors, cell cycle, chemokine signaling, oxidative phosphorylation, renal cell carcinoma, RNA polymerase, VEGF signaling). This evidence concerns the gene VEGFA and hereditary clear cell renal cell carcinoma.