Zhao et al. found that naringenin (100 mg/kg, p.o.)pre-treatment could significantly decrease the serum and BALF levels of IL-1β and IL-6 in an LPS-induced acute lung injury mouse model, which is probably correlated with suppressing the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathways [36]. Here, AKT1 is linked to acute lung injury.