In keeping with elevated molecules necessary for cell adhesion (e.g., VCAM-1, CD11b), and chemotactic signals such as IL-8 produced by immune cells, vascular endothelial cells and hepatocytes, neutrophils of patients with cirrhosis display increased adhesion to microvascular endothelium [65], but impaired ex vivo and in vivo transendothelial migration. The gene discussed is ITGAM; the disease is Cirrhosis.