TFF1 and familial pancreatic carcinoma: Using a transgenic model of PanINs, Shen et al. recently demonstrated the association of early lesions and lymphatic vessels with marked lymphangiogenesis and endothelial remodelling [40], and we have previously shown, in familial pancreatic cancer (FPC), that the overexpression of TFF1 was already present in early PanINs before cancer developed [45].