This study has shown that attenuation of cardiac remodeling, fibrosis, alleviation of the aortic root and coronary arteries atherosclerosis is dependent on the reduction of IL-1β, TNF-α, IL-6 cardiac mRNA expression, and nuclear factor kappa B (NF-κB) activation pathway in RVX pre-treated group. This evidence concerns the gene IL1B and atherosclerosis.