The absence of any significant effect for IL-6 in particular further compounds the conflicting findings in the literature (40), agreeing with the lack of any correlation with depression scores observed by Blackmore et al. (41) at either 18 or 32 weeks’ gestation, but contrasting with reports of positive associations with depressive symptoms in the second trimester (42) as well as trait anxiety and depression scales late in pregnancy (43). This evidence concerns the gene IL6 and depressive disorder.