DUOX1 and chronic obstructive pulmonary disease: For example, the matrix metalloproteinase Mmp-9, which was previously implicated in DUOX1-mediated epithelial wound responses (51) and has also been implicated in COPD as part of the protease/antiprotease imbalance (52), was found to be upregulated in response to chronic acrolein exposure, but this was similar in both WT and Duox1-deficient mice.