To further detect the correlation of GBP1 expression with OS in lung adenocarcinoma patients, univariate Cox's proportional hazard regression was performed, which observed that GBP1 high expression (HR = 2.218, P < .001), worse pathological differentiation (HR = 1.367, P = .013), tumor size >5 cm (HR = 1.620, P = .004), LYN metastasis positive (HR = 3.506, P < .001), higher TNM stage (HR = 1.430, P < .001), and preoperative CEA abnormal (>5 ng/mL) (HR = 2.058, P < .001) were correlated with decreased OS (Table 5). This evidence concerns the gene GBP1 and lung adenocarcinoma.