Therefore, high GBP1 expression was correlated with development and progression of lung adenocarcinoma20; and (b) in addition, GBP1 was reported to be involved in the actin cytoskeleton remodeling process that was an essential event in cell migration, and therefore, we speculated that GBP1 high expression might promote cell motility and invasiveness of lung adenocarcinoma, and further correlate with LYN metastasis and advanced TNM stage in lung adenocarcinoma patients.21 Here, GBP1 is linked to lung adenocarcinoma.