IFNG and hepatocellular carcinoma: Th17 cells have been shown to work synergistically with IFN-γ to produce important antitumor chemokines CXCL10 and CXCL9; however, research indicated that IL-17 was a predictor of poor prognosis in hepatocellular carcinoma patients [46], suggesting the antitumor and protumor immune responses reports may be context dependent.