MiR‐129‐5p overexpression obviously reduced the MMP‐2 and MMP‐9 protein levels and the luciferase activities of NF‐κB, indicating that miR‐129‐5p blocked the NF‐κB pathways to suppress glioma angiogenesis and growth (Figure 4). This evidence concerns the gene NFKB1 and central nervous system cancer.