A previous study focused on mangiferin, a natural polyphenol compound isolated from Anemarrhena asphodeloides, which could be widely found in several higher plants including Mangifera indica L. 112Mangiferin specifically suppresses MMP‐9 mRNA and protein expression in PMA‐stimulated U87MG, U373MG and CRT‐MG glioma cells. Here, MMP9 is linked to central nervous system cancer.