The study conducted gene set enrichment analysis on the CTNNB1 mutant HCC and CTNNB1 wild‐type HCC through the Cancer Genome Atlas (TCGA) database, finding that gene sets significantly up‐regulated in CTNNB1 mutant HCC were all related to metabolism, further confirming the close relationship between CTNNB1 mutation and metabolic reprogramming. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.