When we calculated the ratio of CTF levels over full‐length TDP‐43 levels, an increase in the level of CTF‐35 over the level of full‐length TDP‐43 was observed in ALS cortices compared to PD (p = 0.04) and an increased level of CTF‐25 in ALS compared to CTL, PD, and AD (p = 0.03, p = 0.02, and p = 0.048) in accordance with the enrichment of CTFs in ALS brain tissue (19). Here, TARDBP is linked to amyotrophic lateral sclerosis.