TARDBP and amyotrophic lateral sclerosis: The presence of ubiquitylated cytoplasmic inclusions of the 43 kDa transactive region DNA‐binding protein, TDP‐43, is the neuropathological hallmark of the neurodegenerative disorder amyotrophic lateral sclerosis (ALS) in 97% of all cases and 50% of cases of frontotemporal dementia (FTD) (1, 2).