The neuropathological features of TDP‐43 proteinopathy in ALS and FTD include nuclear to cytoplasmic mislocalization, posttranslational modifications such as ubiquitylation and phosphorylation, aggregation, and N‐terminal truncated C‐terminal TDP‐43 fragments (CTFs) (1, 4). Here, TARDBP is linked to amyotrophic lateral sclerosis.