When calculating the C:N‐terminal peptide ratio to assess the proportion of C‐terminal versus full‐length TDP‐43, a reverse pattern compared to cortex ALS urea fractions was observed, with an unaltered C:N‐terminal peptide ratio when compared to CTL (p = 0.1) (Figure 6C). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.