Interestingly, by this method we were able to identify some cases of AD with coexistent LATE neuropathological change (LATE‐NC); however, further work is required to establish whether our method is suitable for the identification of disease‐specific “TDP‐43 strain signatures” associated with the spectrum of primary and secondary TDP‐43 proteinopathies. Here, TARDBP is linked to Alzheimer disease.