It was experimentally validated by Van Baal et al. that BMP4, a key protein within the development of Barrett’s esophagus (BE) which induces SOX9 mRNA expression and which promotor is activated by GATA6, is negatively regulated via microRNA (miR)-145 (Van Baal et al. 2013). This evidence concerns the gene SOX9 and esophageal adenocarcinoma.