Only four out of the 41 CPDs were found in at least 10% of the screened mammalian orthologs (Supplementary Data S2), with the alternative residue (Isoleucine) in position 39 in MT-ND1 (MI.10998), which is reported in MITOMAP to be associated with maternally-inherited diabetes and deafness (MIM #520000), resulting in being the reference amino acid in 360/674 MT-ND1 orthologs (53.4%). The gene discussed is MT-ND1; the disease is deafness.