PAK4 and hepatocellular carcinoma: miR-199a-3p prompted a diminution of malignant nodular size and numbers in a transgenic mouse model that is prone to developing HCC, coinciding with a downregulation of its putative targets: p21 activated kinase 4 (PAK4) and mTOR, and hence a drop in the levels of FOXM1, replicating effects observed following treatment with sorafenib [114].