The top hub genes included ELANE, APP, MMP9, BMP4, MPO, THBS1, VWF, OLFM4, LCN2, and HOXA7, which significantly enriched in regulation of leukocyte migration, myeloid cell differentiation, extrinsic apoptotic signaling pathway, and monocyte differentiation, associated with cancer. The gene discussed is MMP9; the disease is cancer.