Conversely, the expression levels of LEPR, POMC, MC4R, and NEGR1 in two (GBM and PAAD), two (CHOL and LUSC), four (LUAD, LUSC, PCPG, and THCA), and two (CHOL and PCPG) types of cancer were higher than those of the corresponding normal tissues, respectively. The gene discussed is NEGR1; the disease is cancer.